Gene information
Official symbol FGF2
Official full name fibroblast growth factor 2
Gene type protein-coding gene
Chromosome4q28.1
Previous symbolFGFB
Gene familyReceptor ligands; Fibroblast growth factor family
Resources
Entrez Gene 2247
HGNC HGNC:3676
Ensembl ENSG00000138685
Vega OTTHUMG00000039506
UCSC uc062zki.1
GO terms: 202 records
GO Description Category LogP Number of genes Detail
GO:0001501 skeletal system development GO Biological Processes -17.2073293 69 More
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001657 ureteric bud development GO Biological Processes -9.01105989 19 More
GO:0001658 branching involved in ureteric bud morphogenesis GO Biological Processes -5.14667380 10 More
GO:0001667 ameboidal-type cell migration GO Biological Processes -17.0771232 40 More
GO:0001759 organ induction GO Biological Processes -3.56180292 5 More
GO:0001763 morphogenesis of a branching structure GO Biological Processes -11.2402819 31 More
GO:0001822 kidney development GO Biological Processes -16.2664835 49 More
GO:0001823 mesonephros development GO Biological Processes -9.38463473 20 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001938 positive regulation of endothelial cell proliferation GO Biological Processes -32.0012114 45 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0002040 sprouting angiogenesis GO Biological Processes -8.76593708 16 More
GO:0002065 columnar/cuboidal epithelial cell differentiation GO Biological Processes -7.52899002 17 More
GO:0002067 glandular epithelial cell differentiation GO Biological Processes -3.22341771 8 More
GO:0003156 regulation of animal organ formation GO Biological Processes -3.21663541 6 More
GO:0005125 cytokine activity GO Molecular Functions -54.7097150 57 More
GO:0005178 integrin binding GO Molecular Functions -20.5409412 26 More
GO:0005539 glycosaminoglycan binding GO Molecular Functions -36.7680176 44 More
GO:0006022 aminoglycan metabolic process GO Biological Processes -3.10129957 14 More
GO:0006026 aminoglycan catabolic process GO Biological Processes -3.11015029 4 More
GO:0006644 phospholipid metabolic process GO Biological Processes -2.96272379 13 More
GO:0006650 glycerophospholipid metabolic process GO Biological Processes -2.76007072 11 More
GO:0006816 calcium ion transport GO Biological Processes -5.55009887 27 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0007264 small GTPase mediated signal transduction GO Biological Processes -2.76738893 22 More
GO:0007265 Ras protein signal transduction GO Biological Processes -1.87357952 15 More
GO:0007420 brain development GO Biological Processes -11.5572036 75 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007568 aging GO Biological Processes -23.5429582 29 More
GO:0008083 growth factor activity GO Molecular Functions -26.3260872 31 More
GO:0008201 heparin binding GO Molecular Functions -33.5542939 37 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0008543 fibroblast growth factor receptor signaling pathway GO Biological Processes -3.35297052 5 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009792 embryo development ending in birth or egg hatching GO Biological Processes -12.9988944 72 More
GO:0010001 glial cell differentiation GO Biological Processes -13.0211768 33 More
GO:0010453 regulation of cell fate commitment GO Biological Processes -3.57905448 8 More
GO:0010594 regulation of endothelial cell migration GO Biological Processes -41.8778170 72 More
GO:0010595 positive regulation of endothelial cell migration GO Biological Processes -28.3201829 45 More
GO:0010631 epithelial cell migration GO Biological Processes -10.0481870 21 More
GO:0010632 regulation of epithelial cell migration GO Biological Processes -42.8870194 81 More
GO:0010634 positive regulation of epithelial cell migration GO Biological Processes -29.2566722 52 More
GO:0010762 regulation of fibroblast migration GO Biological Processes -4.05681596 5 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0014842 regulation of skeletal muscle satellite cell proliferation GO Biological Processes -3.34912948 3 More
GO:0014857 regulation of skeletal muscle cell proliferation GO Biological Processes -3.23941104 3 More
GO:0019955 cytokine binding GO Molecular Functions -19.1485102 24 More
GO:0019956 chemokine binding GO Molecular Functions -7.24411974 11 More
GO:0021536 diencephalon development GO Biological Processes -4.93822812 13 More
GO:0021762 substantia nigra development GO Biological Processes -2.58671999 4 More
GO:0021983 pituitary gland development GO Biological Processes -3.57905448 8 More
GO:0021984 adenohypophysis development GO Biological Processes -3.72261873 5 More
GO:0030111 regulation of Wnt signaling pathway GO Biological Processes -7.94227486 39 More
GO:0030203 glycosaminoglycan metabolic process GO Biological Processes -2.99315950 13 More
GO:0030323 respiratory tube development GO Biological Processes -8.11012280 27 More
GO:0030324 lung development GO Biological Processes -8.32855168 27 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0030856 regulation of epithelial cell differentiation GO Biological Processes -15.4645914 35 More
GO:0030858 positive regulation of epithelial cell differentiation GO Biological Processes -9.94639997 18 More
GO:0030879 mammary gland development GO Biological Processes -8.79064244 23 More
GO:0030900 forebrain development GO Biological Processes -11.1545964 48 More
GO:0030901 midbrain development GO Biological Processes -3.06905273 11 More
GO:0031128 developmental induction GO Biological Processes -3.53254248 4 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035270 endocrine system development GO Biological Processes -10.2307745 25 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway GO Biological Processes -4.66781085 9 More
GO:0042056 chemoattractant activity GO Molecular Functions -15.3237868 13 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0042063 gliogenesis GO Biological Processes -20.3412228 47 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043406 positive regulation of MAP kinase activity GO Biological Processes -13.8261343 18 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043534 blood vessel endothelial cell migration GO Biological Processes -6.48443546 10 More
GO:0043536 positive regulation of blood vessel endothelial cell migration GO Biological Processes -25.0316183 33 More
GO:0043542 endothelial cell migration GO Biological Processes -10.6625063 19 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044344 cellular response to fibroblast growth factor stimulus GO Biological Processes -7.12681878 10 More
GO:0045667 regulation of osteoblast differentiation GO Biological Processes -10.7517956 27 More
GO:0045669 positive regulation of osteoblast differentiation GO Biological Processes -8.83631876 18 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0046486 glycerolipid metabolic process GO Biological Processes -5.86759713 18 More
GO:0046620 regulation of organ growth GO Biological Processes -13.2396968 26 More
GO:0046622 positive regulation of organ growth GO Biological Processes -9.67012229 16 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048639 positive regulation of developmental growth GO Biological Processes -14.4198804 35 More
GO:0048660 regulation of smooth muscle cell proliferation GO Biological Processes -48.6624498 69 More
GO:0048661 positive regulation of smooth muscle cell proliferation GO Biological Processes -29.0732096 40 More
GO:0048678 response to axon injury GO Biological Processes -4.04506120 6 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0048754 branching morphogenesis of an epithelial tube GO Biological Processes -10.2965313 26 More
GO:0048857 neural nucleus development GO Biological Processes -2.00492833 4 More
GO:0048863 stem cell differentiation GO Biological Processes -16.2106470 36 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050679 positive regulation of epithelial cell proliferation GO Biological Processes -31.4834672 59 More
GO:0050839 cell adhesion molecule binding GO Molecular Functions -14.4506551 68 More
GO:0050918 positive chemotaxis GO Biological Processes -15.2518887 14 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050921 positive regulation of chemotaxis GO Biological Processes -35.4880405 36 More
GO:0051052 regulation of DNA metabolic process GO Biological Processes -4.01973325 42 More
GO:0051054 positive regulation of DNA metabolic process GO Biological Processes -3.76901955 13 More
GO:0051209 release of sequestered calcium ion into cytosol GO Biological Processes -4.43542328 10 More
GO:0051216 cartilage development GO Biological Processes -10.5011549 17 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051282 regulation of sequestering of calcium ion GO Biological Processes -7.93009971 22 More
GO:0051283 negative regulation of sequestering of calcium ion GO Biological Processes -4.35719226 10 More
GO:0051302 regulation of cell division GO Biological Processes -3.83250874 20 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051781 positive regulation of cell division GO Biological Processes -5.46648014 9 More
GO:0051896 regulation of protein kinase B signaling GO Biological Processes -30.5149255 55 More
GO:0051897 positive regulation of protein kinase B signaling GO Biological Processes -23.7578366 39 More
GO:0055021 regulation of cardiac muscle tissue growth GO Biological Processes -9.70685856 18 More
GO:0055023 positive regulation of cardiac muscle tissue growth GO Biological Processes -8.77845673 13 More
GO:0060043 regulation of cardiac muscle cell proliferation GO Biological Processes -6.20215763 12 More
GO:0060045 positive regulation of cardiac muscle cell proliferation GO Biological Processes -4.61361828 8 More
GO:0060322 head development GO Biological Processes -11.995356 79 More
GO:0060420 regulation of heart growth GO Biological Processes -10.7642352 20 More
GO:0060421 positive regulation of heart growth GO Biological Processes -9.21728400 14 More
GO:0060541 respiratory system development GO Biological Processes -8.30305934 29 More
GO:0060562 epithelial tube morphogenesis GO Biological Processes -17.7630248 53 More
GO:0060675 ureteric bud morphogenesis GO Biological Processes -5.90313372 12 More
GO:0060828 regulation of canonical Wnt signaling pathway GO Biological Processes -5.69122875 29 More
GO:0060976 coronary vasculature development GO Biological Processes -7.60302561 13 More
GO:0060977 coronary vasculature morphogenesis GO Biological Processes -6.32323278 8 More
GO:0060978 angiogenesis involved in coronary vascular morphogenesis GO Biological Processes -4.66190148 3 More
GO:0060993 kidney morphogenesis GO Biological Processes -5.69627654 15 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:0061138 morphogenesis of a branching epithelium GO Biological Processes -11.1441029 30 More
GO:0061180 mammary gland epithelium development GO Biological Processes -3.92752553 10 More
GO:0061326 renal tubule development GO Biological Processes -6.73650560 16 More
GO:0061333 renal tubule morphogenesis GO Biological Processes -6.21761544 14 More
GO:0061448 connective tissue development GO Biological Processes -12.1108226 21 More
GO:0070372 regulation of ERK1 and ERK2 cascade GO Biological Processes -38.4320790 79 More
GO:0070374 positive regulation of ERK1 and ERK2 cascade GO Biological Processes -34.9831828 64 More
GO:0070588 calcium ion transmembrane transport GO Biological Processes -2.54626507 17 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0070851 growth factor receptor binding GO Molecular Functions -16.9609899 22 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071774 response to fibroblast growth factor GO Biological Processes -7.87961599 11 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071902 positive regulation of protein serine/threonine kinase activity GO Biological Processes -13.5008002 23 More
GO:0072001 renal system development GO Biological Processes -17.7796243 52 More
GO:0072006 nephron development GO Biological Processes -8.44009723 23 More
GO:0072009 nephron epithelium development GO Biological Processes -6.83107535 18 More
GO:0072028 nephron morphogenesis GO Biological Processes -6.21761544 14 More
GO:0072073 kidney epithelium development GO Biological Processes -9.16824163 24 More
GO:0072078 nephron tubule morphogenesis GO Biological Processes -5.75203434 13 More
GO:0072080 nephron tubule development GO Biological Processes -6.27678757 15 More
GO:0072088 nephron epithelium morphogenesis GO Biological Processes -5.59038404 13 More
GO:0072163 mesonephric epithelium development GO Biological Processes -8.91550162 19 More
GO:0072164 mesonephric tubule development GO Biological Processes -8.91550162 19 More
GO:0072171 mesonephric tubule morphogenesis GO Biological Processes -5.80850319 12 More
GO:0090130 tissue migration GO Biological Processes -11.7623300 24 More
GO:0090132 epithelium migration GO Biological Processes -9.75855830 21 More
GO:0090263 positive regulation of canonical Wnt signaling pathway GO Biological Processes -2.20870076 11 More
GO:0090287 regulation of cellular response to growth factor stimulus GO Biological Processes -21.1381780 60 More
GO:0090288 negative regulation of cellular response to growth factor stimulus GO Biological Processes -9.39414218 23 More
GO:0090407 organophosphate biosynthetic process GO Biological Processes -3.52771570 18 More
GO:0097553 calcium ion transmembrane import into cytosol GO Biological Processes -4.27502414 13 More
GO:1901136 carbohydrate derivative catabolic process GO Biological Processes -3.37180259 9 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901681 sulfur compound binding GO Molecular Functions -28.2504512 39 More
GO:1902893 regulation of miRNA transcription GO Biological Processes -10.5909336 18 More
GO:1902895 positive regulation of miRNA transcription GO Biological Processes -9.50703189 15 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
GO:1903510 mucopolysaccharide metabolic process GO Biological Processes -2.64314024 10 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:1905330 regulation of morphogenesis of an epithelium GO Biological Processes -7.22524154 15 More
GO:2000027 regulation of animal organ morphogenesis GO Biological Processes -7.86416421 22 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000177 regulation of neural precursor cell proliferation GO Biological Processes -5.62902185 15 More
GO:2000179 positive regulation of neural precursor cell proliferation GO Biological Processes -3.60984508 9 More
KEGG pathways: 14 records
KEGG Description Category LogP Number of genes Detail
hsa01521 EGFR tyrosine kinase inhibitor resistance KEGG Pathway -6.02704244 9 More
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04015 Rap1 signaling pathway KEGG Pathway -8.52596130 17 More
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04550 Signaling pathways regulating pluripotency of stem cells KEGG Pathway -2.54669304 7 More
hsa04810 Regulation of actin cytoskeleton KEGG Pathway -10.0068804 19 More
hsa05167 Kaposi sarcoma-associated herpesvirus infection KEGG Pathway -9.05308086 17 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05205 Proteoglycans in cancer KEGG Pathway -18.5545131 27 More
hsa05207 Chemical carcinogenesis - receptor activation KEGG Pathway -7.05448873 28 More
hsa05224 Breast cancer KEGG Pathway -6.01672252 21 More
hsa05226 Gastric cancer KEGG Pathway -5.33653529 20 More
Drug-Gene interaction
view
Related drugs: 21 records
Drug name Interaction type Source PMID View
abt-510 NCI 16051960 view
aspirin NCI 9071932 view
atorvastatin NCI 12147302 view
caffeine NCI 15738284 view
famotidine NCI 11943947 view
fluvoxamine PharmGKB view
fp-1039 suppressor TALC view
indomethacin NCI 9071932 view
lenalidomide PharmGKB 28373444 view
muparfostat inhibitor ChemblInteractions view
phenylephrine NCI 15875663 view
pyrazole NCI 9730230 view
quizartinib CIViC 27671675 view
rebamipide NCI 8774986 view
sirolimus other/unknown TdgClinicalTrial 12742462 view
squalamine TTD view
sucralfate induceragonist TTD 79488258578218195712419703378578198 view
thalidomide PharmGKB 28373444 view
thyrotropin NCI 7519916 view
triamcinolone NCI 15923512 view
vincristine NCI 8988045 view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
fibroblast growth factor 2 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Tamura K et al. Jpn Circ J. 1999
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